業務目録

2017年度

・ Kabeshita Y, Adachi H, Matsushita M, Kanemoto H, Sato S, Suzuki Y, Yoshiyama K, Shimomura T, Yoshida T, Shimizu H, Matsumoto T, Mori T, Kashibayashi T, Tanaka H, Hatada Y, Hashimoto M, Nishio Y, Komori K, Tanaka T, Yokoyama K, Tanimukai S, Ikeda M, Takeda M, Mori E, Kudo T, Kazui H. Sleep disturbances are key symptoms of very early stage Alzheimer disease with behavioral and psychological symptoms: a Japan multi-center cross-sectional study (J-BIRD). Int J Geriatr Psychiatry 32(2); 222-230, 2017
・ Yamashita N, Kuzuoka H, Hirata K, Kudo T, Aramaki E, Hattori K Changing Moods: How Manual Tracking by Family Caregivers Improves Caring and Family Communication. CHI 2017, May 06 - 11, 2017
・ Mizuta N, Yanagida K, Kodama T, Tomonaga T, Takami M, Oyama H, Kudo T, Ikeda M, Takeda M, Tagami S, Okochi M. Identification of Small Peptides in Human Cerebrospinal Fluid upon Amyloid-β Degradation. Neurodegener Dis. 17(2-3):103-109, 2017
・ Yamashita N, Kuzuoka H, Hirata K, Kudo T, Aramaki E, Hattori K. Changing Moods: How Manual Tracking by Family Caregivers Improves Caring and Family Communication. CHI 2017, May 06 - 11, 2017
・ Tanaka H, Adachi H, Ukita N, Ikeda M, Kazui H, Kudo T, Nakamura S. Detecting Dementia Through Interactive Computer Avatars. IEEE J Transl Eng Health Med. 2017 Sep 15;5:2200111. doi: 10.1109/JTEHM.2017.2752152. eCollection 2017
・ Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M. Semagacestat Is a Pseudo-Inhibitor of γ-Secretase Cell Rep. 21(1):259-273, 2017.
・ Yasuno F, Kudo T, Yamamoto A, Matsuoka K, Takahashi M, Iida H, Ihara M, Nagatsuka K, Kishimoto T. Significant correlation between openness personality in normal subjects and brain myelin mapping with T1/T2-weighted MR imaging. Heliyon. 2017 Sep 22;3(9):e00411.
・ Matsuoka K, Yasuno F, Kishimoto T, Yamamoto A, Kiuchi K, Kosaka J, Nagatsuka K, Iida H, Kudo T. Microstructural Differences in the Corpus Callosum in Patients With Bipolar Disorder and Major Depressive Disorder. J Clin Psychiatry 78(1):99-104.2017
・ Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Mol Med.9(10):1356-1365.2017
・ Trambauer J, Fukumori A, Kretner B, Steiner H. Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators. Methods Enzymol.584:157-183.2017

2016年度

・ Trambauer J, Fukumori A, Kretner B, Steiner H. Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators. Methods Enzymol. 2017;584:157-183, 2016
・ Fukumori A. and Steiner H Substrate Recruitment of γ-Secretase and Mechanism of Clinical Presenilin Mutations Revealed by Photoaffinity Mapping. EMBO J. 35(15):1628-1643, 2016
・ Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer’s disease. EMBO Mol Med. 8(5):458-465, 2016
・ Huttl S, Helfrich F, Mentrup T, Held S, Fukumori A, Steiner H, Saftig P, Fluhrer R, Schroder B. Substrate determinants of Signal peptide peptidase-like 2a (SPPL2a)-mediated Intramembrane Proteolysis of the Invariant chain CD74. Biochem J. 473(10):1405-1422, 2016
・ Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kroper M, Rossner MJ, Fluhrer R, Willem M, Haass C. (2016): Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases. J Biol Chem . 291(1):318-333, 2016
・ Nonoue S, Mashita M, Haraki S, Mikami A, Adachi H, Yatani H, Yoshida A, Taniike M, Kato T. Inter-scorer reliability of sleep assessment using EEG and EOG recording system in comparison to polysomnography. Sleep and Biological Rhythms, in press, 2016

2015年度

・ Matsuoka K, Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Sekiyama A, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K Delayed atrophy in posterior cingulate cortex and apathy after stroke. Int J Geriatr Psychiatry 30: 566-572, 2015
・ Tanimukai H, Adachi H, Hirai K, Matsui T, Shimizu M, Miyashita M, Tsuneto S, Shima Y Association between depressive symptoms and changes in sleep condition in the grieving process. Supportive Care in Cancer 23(7); 1925-1931, 2015

2014年度

・ Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice T, Chevallier N, Marchal S, Takeda M, Kudo T Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death and Disease 5, e1332, 2014
・ Yasuno F, Taguchi A, Kikuchi-Taura A, Yamamoto A, Kazui H, Kudo T, Sekiyama A, Kajimoto K, Soma T, Kishimoto T, Iida H, Nagatsuka K Possible Protective Effect of Regulatory T cells on White Matter Microstructural Abnormalities in Stroke Patients. Clinical & Cellular Immunology 5(3): 1000221, 2014
・ Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier. Proc. Natl. Acad. Sci. USA 111(7):2638-2643, 2014
・ Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Kikuchi-Taura A, Sekiyama A, Kishimoto T, Iida H, Nagatsuka K Microstructural abnormality in white matter, regulatory T lymphocyte, and depressive symptoms after stroke. Psychogeriatrics, 14:213-221, 2014
・ Tanimukai H, Hirai K, Adachi H, Kishi A Sleep problems and psychological distress in family members of patients with hematological malignancies in the Japanese population. Annals of Hematology 93(12); 2067-2075, 2014

2013年度

・ Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M Involvement of endoplasmic reticulum stress in tauopathy. Biochem Biophys Res Commun. 430(2):500-504, 2013
・ Nakanishi T, Shimazawa M, Sugitani S, Kudo T, Imai S, Inokuchi Y, Tsuruma K, Hara H Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice. J Neurochem. 125(1):111-124, 2013
・ Tamimukai H, Kanayama D, Omi T, Takeda M, Kudo T Paclitaxel induces neurotoxicity through endoplasmic reticulum stress. Biochem Biophys Res Commun. 43:151-155, 2013
・ Yamashita N, Kuzuoka H, Hirata K, Kudo T Understanding the Conflicting Demands of Family Caregivers Caring for Depressed Family Members. CHI2013: 2637-2646, 2013.
・ Mikami A, Matsushita M, Adachi H, Suganuma N, Koyama A, Ichimi N, Ushijima H, Ikeda M, Takeda M, Moriyama T, Sugita Y  Sense of coherence, health problems and presenteeism in Japanese university students. Asian Journal of Psychiatry 6(5); 369-372, 2013
・ Adachi H, Shinagawa S, Komori K, Toyota Y, Mori T, Matsumoto T, Sonobe N, Kashibayashi T, Ishikawa T, Fukuhara R, Ikeda M Comparison of the utility of the everyday memory test and the Alzheimer’s Disease Assessment Scale-Cognitive part (ADAS-Cog) for evaluation of mild cognitive impairment (MCI) and very mild Alzheimer’s disease (AD). Psychiatry and Clinical Neurosciences 67(3);148-153, 2013

2012年度

・ Mikami A, Matsushita M, Watanabe T, Sugiyama E, Adachi H, Matsuura R, Sugita Y, Takeda M Sleep Debt Must be Paid Off: Relationship Between Sleep Loss and Mental Health Among Japanese Workers. The Open Sleep Journal 5;25-32, 2012

2011年度

・ Kimura R, Morihara T, Kudo T, Kamino K, Takeda M Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population. Neurosci Let 487: 354-357, 2011
・ Ishisaka M, Kudo T, Shimazawa M, Kakefuda K, Oyagi A, Hyakkoku K, Tsuruma K, Hara H Restraint-Induced Expression of Endoplasmic Reticulum Stress-Related Genes in the Mouse Brain Pharmacology & Pharmacy, 2(1): 10-16, 2011
・ Furuichi T, Masuya H, Murakami T, Nishida K, Nishimura G, Suzuki T, Imaizumi K, Kudo T, Ohkawa K, Wakana S, Ikegawa S ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse of platyspondylic lethal skeletal dysplasia, Torrance type Mamm Genome 22(5-6):318-328. 2011
・ Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser87 to suppress apoptotic cell death. Psychogeriatrics 11(2): 90-97, 2011
・ Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Takeda M Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress. Biochem Biophys Res Commun. 415(3):519-525, 2011

2010年度

・ Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama T, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel Psychogeriatrics 10:117-123, 2010
・ Hino S-I, Kondo S, Yoshinaga K, Saito A, Murakami T, Kanemoto S, Sekiya H, Chihara K, Aikawa Y, Hara H, Kudo T, Sekimoto T, Funamoto T, Chosa E, and Imaizumi K Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis J Bone Miner Metab 28:131-138, 2010
・ Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M. The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 153B(8):1459-64, 2010
・ Oida Y, Hamanaka J, Hyakkoku K, Shimazawa M, Kudo T, Imaizumi K, Yasuda T, Hara H Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice Neurosci Let 484: 43-46,2010
・ Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M KIBRA Genetic Polymorphism Influences Episodic Memory in Alzheimer's Disease, but Does Not Show Association with Disease in a Japanese Cohort. Dement Geriatr Cogn Disord. 25;30(4):302-308. 2010

2009年度

・ Inokuchi Y, Nakajima Y, Shimazawa M, Kurita T, Kubo M, Saito A, Sajiki H, Kudo T, Aihara M, Imaizumi K, Araie M, Hara H Effect of an Inducer of BiP, a Molecular Chaperone, on Endoplasmic Reticulum (ER) Stress-Induced Retinal Cell Death Invest Ophthalmol Vis Sci 50: 334-344,2009
・ Kamagata E, Kudo T, Kimura R, Tanimukai H, Morihara T, Sadik M, Kamino K, Takeda M Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Aβ metabolism Biochem Biophys Res Commun 379: 691-695, 2009
・ Sadik G, Tanaka T, Kato K, Yanagi K, Kudo T, Takeda M Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein. Biochem Biophys Res Commun. 383(1):37-41, 2009
・ Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Fukumoto M, Takamura H, Iwase M, Kamino K, Ishii R, Kazui H, Sekiyama R, Kitamura Y, Azechi M, Ikezawa K, Kurimoto R, Kamagata E, Tanimukai H, Tagami S, Morihara T, Ogasawara M, Okochi M, Tokunaga H, Numata S, Ikeda M, Ohnuma T, Ueno S, Fukunaga T, Tanaka T, Kudo T, Arai H, Ohmori T, Iwata N, Ozaki N, Takeda M Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study Schizophr Res. 109(1-3):80-85, 2009
・ Yanagi K, Tanaka T, Kato K, Sadik G, Morihara T, Kudo T, Takeda M Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau Psychogeriatrics 9:157-166, 2009
・ Kimura R, Yamamoto M, Morihara T, Akatsu H, Kudo T, Kamino K, Takeda M SORL1 is genetically associated with Alzheimer disease in a Japanese population. Neurosci Lett. 461(2):177-180, 2009

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